Anabolism-associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-renewal

Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of opposing metabolic states. Differentiation driven by...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Adams, William C., Chen, Yen-Hua, Kratchmarov, Radomir, Yen, Bonnie, Nish, Simone A., Lin, Wen-Hsuan W., Rothman, Nyanza J., Luchsinger, Larry L., Klein, Ulf, Busslinger, Meinrad, Rathmell, Jeffrey C., Snoeck, Hans-Willem, Reiner, Steven L.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189677/
https://ncbi.nlm.nih.gov/pubmed/28009285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.065
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