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Anabolism-associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-renewal
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of opposing metabolic states. Differentiation driven by...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5189677/ https://ncbi.nlm.nih.gov/pubmed/28009285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.065 |
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