Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional networks and fates of kindred cells. A sibling B lymph...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Lin, Wen-Hsuan W., Adams, William C., Nish, Simone A., Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J., Kratchmarov, Radomir, Okada, Takaharu, Klein, Ulf, Reiner, Steven L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685001/
https://ncbi.nlm.nih.gov/pubmed/26628372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.072
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