Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional networks and fates of kindred cells. A sibling B lymph...

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Publicat a:Cell Rep
Autors principals: Lin, Wen-Hsuan W., Adams, William C., Nish, Simone A., Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J., Kratchmarov, Radomir, Okada, Takaharu, Klein, Ulf, Reiner, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685001/
https://ncbi.nlm.nih.gov/pubmed/26628372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.072
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