Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional networks and fates of kindred cells. A sibling B lymph...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lin, Wen-Hsuan W., Adams, William C., Nish, Simone A., Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J., Kratchmarov, Radomir, Okada, Takaharu, Klein, Ulf, Reiner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685001/
https://ncbi.nlm.nih.gov/pubmed/26628372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.072
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