Anabolism-associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-renewal

Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of opposing metabolic states. Differentiation driven by...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Adams, William C., Chen, Yen-Hua, Kratchmarov, Radomir, Yen, Bonnie, Nish, Simone A., Lin, Wen-Hsuan W., Rothman, Nyanza J., Luchsinger, Larry L., Klein, Ulf, Busslinger, Meinrad, Rathmell, Jeffrey C., Snoeck, Hans-Willem, Reiner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189677/
https://ncbi.nlm.nih.gov/pubmed/28009285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.065
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