CD8(+) T Lymphocyte Self-renewal during Effector Cell Determination

Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells, and that this requires cell division. In acute infections, the f...

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Udgivet i:Cell Rep
Main Authors: Lin, Wen-Hsuan W., Nish, Simone A., Yen, Bonnie, Chen, Yen-Hua, Adams, William C., Kratchmarov, Radomir, Rothman, Nyanza J., Bhandoola, Avinash, Xue, Hai-Hui, Reiner, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108530/
https://ncbi.nlm.nih.gov/pubmed/27829149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.032
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