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Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Li, Shao, Wang, Xi, Ma, Quan-Hong, Yang, Wu-lin, Zhang, Xiao-Gang, Dawe, Gavin S., Xiao, Zhi-Cheng
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://ncbi.nlm.nih.gov/pubmed/28008944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320
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