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Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway
Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/ https://ncbi.nlm.nih.gov/pubmed/28008944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320 |
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