Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Li, Shao, Wang, Xi, Ma, Quan-Hong, Yang, Wu-lin, Zhang, Xiao-Gang, Dawe, Gavin S., Xiao, Zhi-Cheng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://ncbi.nlm.nih.gov/pubmed/28008944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items