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Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway
Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/ https://ncbi.nlm.nih.gov/pubmed/28008944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320 |
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