Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)

Aberrant increases in neuronal network excitability may contribute to the cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of neuronal networks has been detected in the brains of APP/PS1 mice. In t...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Wang, Xi, Zhang, Xiao-Gang, Zhou, Ting-Ting, Li, Na, Jang, Chun-Yan, Xiao, Zhi-Cheng, Ma, Quan-Hong, Li, Shao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Psychiatry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783403/
https://ncbi.nlm.nih.gov/pubmed/27013956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00094
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