CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons in normal an...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Zybura, Agnes S., Baucum, Anthony J., Rush, Anthony M., Cummins, Theodore R., Hudmon, Andy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450116/
https://ncbi.nlm.nih.gov/pubmed/32611770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014062
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