CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons in normal an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zybura, Agnes S., Baucum, Anthony J., Rush, Anthony M., Cummins, Theodore R., Hudmon, Andy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450116/
https://ncbi.nlm.nih.gov/pubmed/32611770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014062
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