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Distinctive Properties and Powerful Neuromodulation of Na(v)1.6 Sodium Channels Regulates Neuronal Excitability

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Na(v)1.6 is highly enriched at the axon initial segment and nodes, making it critic...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Zybura, Agnes, Hudmon, Andy, Cummins, Theodore R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307729/
https://ncbi.nlm.nih.gov/pubmed/34202119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071595
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