Distinct repriming and closed-state inactivation kinetics of Na(v)1.6 and Na(v)1.7 sodium channels in mouse spinal sensory neurons

While large, myelinated dorsal root ganglion (DRG) neurons are capable of firing at high frequencies, small unmyelinated DRG neurons typically display much lower maximum firing frequencies. However, the molecular basis for this difference has not been delineated. Because the sodium currents in large...

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Main Authors: Herzog, Raimund I, Cummins, Theodore R, Ghassemi, Farshid, Dib-Hajj, Sulayman D, Waxman, Stephen G
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2003
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343279/
https://ncbi.nlm.nih.gov/pubmed/12843211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.047357
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