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Distinctive Properties and Powerful Neuromodulation of Na(v)1.6 Sodium Channels Regulates Neuronal Excitability

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Na(v)1.6 is highly enriched at the axon initial segment and nodes, making it critic...

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Pubblicato in:Cells
Autori principali: Zybura, Agnes, Hudmon, Andy, Cummins, Theodore R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307729/
https://ncbi.nlm.nih.gov/pubmed/34202119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071595
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