Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel Na(V)1.6 by Calmodulin

The neuronal-voltage gated sodium channel (VGSC), Na(V)1.6, plays an important role in propagating action potentials along myelinated axons. Calmodulin (CaM) is known to modulate the inactivation kinetics of Na(V)1.6 by interacting with its IQ motif. Here we report the crystal structure of apo-CaM:N...

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Bibliographic Details
Main Authors:	Chichili, Vishnu Priyanka Reddy, Xiao, Yucheng, Seetharaman, J., Cummins, Theodore R., Sivaraman, J.
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3743062/ https://ncbi.nlm.nih.gov/pubmed/23942337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02435
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Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel Na(V)1.6 by Calmodulin

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