Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel Na(V)1.6 by Calmodulin

The neuronal-voltage gated sodium channel (VGSC), Na(V)1.6, plays an important role in propagating action potentials along myelinated axons. Calmodulin (CaM) is known to modulate the inactivation kinetics of Na(V)1.6 by interacting with its IQ motif. Here we report the crystal structure of apo-CaM:N...

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Detaylı Bibliyografya
Asıl Yazarlar: Chichili, Vishnu Priyanka Reddy, Xiao, Yucheng, Seetharaman, J., Cummins, Theodore R., Sivaraman, J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743062/
https://ncbi.nlm.nih.gov/pubmed/23942337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02435
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