Structural Basis for the Interaction of Unstructured Neuron Specific Substrates Neuromodulin and Neurogranin with Calmodulin

Neuromodulin (Nm) and neurogranin (Ng) are neuron-specific substrates of protein kinase C (PKC). Their interactions with Calmodulin (CaM) are crucial for learning and memory formation in neurons. Here, we report the structure of IQ peptides (24aa) of Nm/Ng complexed with CaM and their functional stu...

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Detalhes bibliográficos
Main Authors: Kumar, Veerendra, Chichili, Vishnu Priyanka Reddy, Zhong, Ling, Tang, Xuhua, Velazquez-Campoy, Adrian, Sheu, Fwu-Shan, Seetharaman, J., Gerges, Nashaat Z., Sivaraman, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589724/
https://ncbi.nlm.nih.gov/pubmed/23462742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01392
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