CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons in normal an...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Zybura, Agnes S., Baucum, Anthony J., Rush, Anthony M., Cummins, Theodore R., Hudmon, Andy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450116/
https://ncbi.nlm.nih.gov/pubmed/32611770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014062
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