CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons in normal an...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Zybura, Agnes S., Baucum, Anthony J., Rush, Anthony M., Cummins, Theodore R., Hudmon, Andy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450116/
https://ncbi.nlm.nih.gov/pubmed/32611770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014062
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