Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel Na(V)1.5 Gating by Multiple Phosphorylation Sites

The cardiac Na(+) channel Na(V)1.5 current (I(Na)) is critical to cardiac excitability, and altered I(Na) gating has been implicated in genetic and acquired arrhythmias. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is up-regulated in heart failure and has been shown to cause I(Na) gating c...

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Autori principali: Ashpole, Nicole M., Herren, Anthony W., Ginsburg, Kenneth S., Brogan, Joseph D., Johnson, Derrick E., Cummins, Theodore R., Bers, Donald M., Hudmon, Andy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370170/
https://ncbi.nlm.nih.gov/pubmed/22514276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322537
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