Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability

Aberrant glutamate and calcium signalings are neurotoxic to specific neuronal populations. Calcium/calmodulin-dependent kinase II (CaMKII), a multifunctional serine/threonine protein kinase in neurons, is believed to regulate neurotransmission and synaptic plasticity in response to calcium signaling...

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Autors principals: Ashpole, Nicole M., Song, Weihua, Brustovetsky, Tatiana, Engleman, Eric A., Brustovetsky, Nickolay, Cummins, Theodore R., Hudmon, Andy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318689/
https://ncbi.nlm.nih.gov/pubmed/22253441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323915
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