Loss of Calcium/Calmodulin-dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP

The extent of calcium/calmodulin-dependent protein kinase II (CaMKII) inactivation in the brain after ischemia correlates with the extent of damage. We have previously shown that a loss of CaMKII activity in neurons is detrimental to neuronal viability by inducing excitotoxic glutamate release. In t...

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Detalhes bibliográficos
Main Authors: Ashpole, Nicole M., Chawla, Aarti R., Martin, Matthew P., Brustovetsky, Tatiana, Brustovetsky, Nickolay, Hudmon, Andy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656312/
https://ncbi.nlm.nih.gov/pubmed/23543737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466235
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