Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)

Aberrant increases in neuronal network excitability may contribute to the cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of neuronal networks has been detected in the brains of APP/PS1 mice. In t...

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Udgivet i:Front Neurosci
Main Authors: Wang, Xi, Zhang, Xiao-Gang, Zhou, Ting-Ting, Li, Na, Jang, Chun-Yan, Xiao, Zhi-Cheng, Ma, Quan-Hong, Li, Shao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Psychiatry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783403/
https://ncbi.nlm.nih.gov/pubmed/27013956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00094
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