Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Li, Shao, Wang, Xi, Ma, Quan-Hong, Yang, Wu-lin, Zhang, Xiao-Gang, Dawe, Gavin S., Xiao, Zhi-Cheng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://ncbi.nlm.nih.gov/pubmed/28008944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320
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