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Amyloid Precursor Protein Enhances Nav1.6 Sodium Channel Cell Surface Expression
Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 is a key determinant of neuronal excitability in vivo. Because mouse models of gain of function and loss of function of APP and Nav1.6 share some similar phenotypes,...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424341/ https://ncbi.nlm.nih.gov/pubmed/25767117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617092 |
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