Amyloid Precursor Protein Enhances Nav1.6 Sodium Channel Cell Surface Expression

Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 is a key determinant of neuronal excitability in vivo. Because mouse models of gain of function and loss of function of APP and Nav1.6 share some similar phenotypes,...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Liu, Chao, Tan, Francis Chee Kuan, Xiao, Zhi-Cheng, Dawe, Gavin S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Neurobiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424341/
https://ncbi.nlm.nih.gov/pubmed/25767117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617092
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