Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Li, Shao, Wang, Xi, Ma, Quan-Hong, Yang, Wu-lin, Zhang, Xiao-Gang, Dawe, Gavin S., Xiao, Zhi-Cheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://ncbi.nlm.nih.gov/pubmed/28008944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39320
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