Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses

Acquisition of a polybasic cleavage site (pCS) in the hemagglutinin (HA) is a prerequisite for the shift of low pathogenic (LP) avian influenza virus (AIV) to the highly pathogenic (HP) form in chickens. Whereas presence of a pCS is required for high pathogenicity, less is known about the effect of...

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Publicado en:Sci Rep
Autores principales: Abdelwhab, E. M., Veits, Jutta, Ulrich, Reiner, Kasbohm, Elisa, Teifke, Jens P., Mettenleiter, Thomas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177941/
https://ncbi.nlm.nih.gov/pubmed/28004772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39505
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