A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens

In 1999, after circulation for a few months in poultry in Italy, low-pathogenic (LP) avian influenza (AI) H7N1 virus mutated into a highly pathogenic (HP) form by acquisition of a unique multibasic cleavage site (mCS), PEIPKGSRVRR*GLF (asterisk indicates the cleavage site), in the hemagglutinin (HA)...

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Bibliografiska uppgifter
I publikationen:J Virol
Huvudupphovsmän: Abdelwhab, El-Sayed M., Veits, Jutta, Tauscher, Kerstin, Ziller, Mario, Teifke, Jens P., Stech, Jürgen, Mettenleiter, Thomas C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Genetic Diversity and Evolution
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702528/
https://ncbi.nlm.nih.gov/pubmed/26491158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02082-15
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