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p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis
Mutations in the oligomerization domain of p53 are genetically linked to cancer susceptibility in Li-Fraumeni Syndrome. These mutations typically alter the oligomeric state of p53 and impair its transcriptional activity. Activation of p53 through tetramerization is required for its tumor suppressive...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5176156/ https://ncbi.nlm.nih.gov/pubmed/27754743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1241917 |
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