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Association Between the Oligomeric Status of p53 and Clinical Outcomes in Li-Fraumeni Syndrome
Li-Fraumeni syndrome (LFS) is a rare hereditary cancer disorder with highly variable clinical outcomes that results from germline mutations in the TP53 gene. Here we report that the quaternary structure of p53 is an important factor affecting cellular functions and the clinical outcomes of LFS patie...
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| Publicado no: | J Natl Cancer Inst |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6292786/ https://ncbi.nlm.nih.gov/pubmed/29955864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy114 |
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