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Inherited TP53 Mutations and the Li–Fraumeni Syndrome

Li–Fraumeni syndrome (LFS) is a complex hereditary cancer predisposition disorder associated with early-onset cancers in diverse tissues of origin. Germline TP53 mutations are identified in 75% of patients with classic LFS. The lifetime likelihood of a TP53 mutation carrier developing cancer approac...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Med
Main Authors: Guha, Tanya, Malkin, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378014/
https://ncbi.nlm.nih.gov/pubmed/28270529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026187
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