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Inherited TP53 Mutations and the Li–Fraumeni Syndrome
Li–Fraumeni syndrome (LFS) is a complex hereditary cancer predisposition disorder associated with early-onset cancers in diverse tissues of origin. Germline TP53 mutations are identified in 75% of patients with classic LFS. The lifetime likelihood of a TP53 mutation carrier developing cancer approac...
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| Pubblicato in: | Cold Spring Harb Perspect Med |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378014/ https://ncbi.nlm.nih.gov/pubmed/28270529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026187 |
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