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TP53 Testing and Li-Fraumeni Syndrome: Current Status of Clinical Applications and Future Directions
Prevalent as an acquired abnormality in cancer, the role of TP53 as a germline mutation continues to evolve. The clinical impact of a germline TP53 mutation is often dramatic and affects the full life course, with a propensity to develop rare tumors in childhood and multiple common cancers of unexpe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627545/ https://ncbi.nlm.nih.gov/pubmed/23355100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40291-013-0020-0 |
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