Breast Cancer Phenotype in Women with TP53 Germline Mutations: a Li Fraumeni Syndrome Consortium Effort

BACKGROUND: Breast cancer is the most common tumor in women with Li Fraumeni Syndrome (LFS), an inherited cancer syndrome associated with germline mutations in the TP53 tumor suppressor gene. Their lifetime breast cancer risk is 49% by age 60. Breast cancers in TP53 carriers have recently been repor...

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Autori principali: Masciari, Serena, Dillon, Deborah A., Rath, Michelle, Robson, Mark, Weitzel, Jeffrey N., Balmana, Judith, Gruber, Stephen B., Ford, James M., Euhus, David, Lebensohn, Alexandra, Telli, Melinda, Pochebit, Stephen M., Lypas, Georgios, Garber, Judy E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709568/
https://ncbi.nlm.nih.gov/pubmed/22392042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-1993-9
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