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Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage
Poly(ADP-ribose) (PAR) is a posttranslational modification predominantly synthesized by PAR polymerase-1 (PARP-1) in genome maintenance. PARP-1 detects DNA damage, and damage detection is coupled to a massive increase PAR production, primarily attached to PARP-1 (automodification). Automodified PARP...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5175350/ https://ncbi.nlm.nih.gov/pubmed/27530425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw710 |
| Oznake: |
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