PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

Poly(ADP-ribose) polymerase-2 (PARP-2) is one of three human PARP enzymes that are potently activated during the cellular DNA damage response (DDR). DDR-PARPs detect DNA strand breaks, leading to a dramatic increase in their catalytic production of the posttranslational modification poly(ADP-ribose)...

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Udgivet i:Nucleic Acids Res
Main Authors: Riccio, Amanda A., Cingolani, Gino, Pascal, John M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770219/
https://ncbi.nlm.nih.gov/pubmed/26704974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1376
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