Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

DNA breaks recruit and activate PARP1/2, which deposit poly-ADP-ribose (PAR) to recruit XRCC1-Ligase3 and other repair factors to promote DNA repair. Clinical PARP inhibitors (PARPi) extend the lifetime of damage-induced PARP1/2 foci, referred to as ‘trapping’. To understand the molecular nature of...

全面介紹

Na minha lista:
書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Shao, Zhengping, Lee, Brian J, Rouleau-Turcotte, Élise, Langelier, Marie-France, Lin, Xiaohui, Estes, Verna M, Pascal, John M, Zha, Shan
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Genome Integrity, Repair and Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515702/
https://ncbi.nlm.nih.gov/pubmed/32890402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa718
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍