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PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
Poly(ADP-ribose) polymerase 1 (PARP-1) regulates gene transcription, cell death signaling, and DNA repair through production of the posttranslational modification poly(ADP-ribose). During the cellular response to genotoxic stress PARP-1 rapidly associates with DNA damage, which robustly stimulates p...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572337/ https://ncbi.nlm.nih.gov/pubmed/23333033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2013.01.003 |
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