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PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks
After the generation of DNA double-strand breaks (DSBs), poly(ADP-ribose) polymerase-1 (PARP-1) is one of the first proteins to be recruited and activated through its binding to the free DNA ends. Upon activation, PARP-1 uses NAD(+) to generate large amounts of poly(ADP-ribose) (PAR), which facilita...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488241/ https://ncbi.nlm.nih.gov/pubmed/22941645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks798 |
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