PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks

After the generation of DNA double-strand breaks (DSBs), poly(ADP-ribose) polymerase-1 (PARP-1) is one of the first proteins to be recruited and activated through its binding to the free DNA ends. Upon activation, PARP-1 uses NAD(+) to generate large amounts of poly(ADP-ribose) (PAR), which facilita...

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Detalhes bibliográficos
Main Authors: Krietsch, Jana, Caron, Marie-Christine, Gagné, Jean-Philippe, Ethier, Chantal, Vignard, Julien, Vincent, Michel, Rouleau, Michèle, Hendzel, Michael J., Poirier, Guy G., Masson, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488241/
https://ncbi.nlm.nih.gov/pubmed/22941645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks798
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