Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors. Here, we identify a function for PARP-1...

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Publicado no:Nat Commun
Main Authors: Caron, Marie-Christine, Sharma, Ajit K., O’Sullivan, Julia, Myler, Logan R., Ferreira, Maria Tedim, Rodrigue, Amélie, Coulombe, Yan, Ethier, Chantal, Gagné, Jean-Philippe, Langelier, Marie-France, Pascal, John M., Finkelstein, Ilya J., Hendzel, Michael J., Poirier, Guy G., Masson, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609622/
https://ncbi.nlm.nih.gov/pubmed/31273204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10741-9
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