DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

RNA synthesis and DNA replication cease after DNA damage. We studied RNA synthesis using an in situ run-on assay and found ribosomal RNA (rRNA) synthesis was inhibited 24 h after UV light, gamma radiation or DNA cross-linking by cisplatin in human cells. Cisplatin led to accumulation of cells in S p...

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Detaylı Bibliyografya
Asıl Yazarlar: Calkins, Anne S., Iglehart, J. Dirk, Lazaro, Jean-Bernard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Genome Integrity, Repair and Replication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753630/
https://ncbi.nlm.nih.gov/pubmed/23775790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt502
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