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DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
RNA synthesis and DNA replication cease after DNA damage. We studied RNA synthesis using an in situ run-on assay and found ribosomal RNA (rRNA) synthesis was inhibited 24 h after UV light, gamma radiation or DNA cross-linking by cisplatin in human cells. Cisplatin led to accumulation of cells in S p...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753630/ https://ncbi.nlm.nih.gov/pubmed/23775790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt502 |
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