Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks

In mammalian cells, the main pathway for DNA double-strand breaks (DSBs) repair is classical non-homologous end joining (C-NHEJ). An alternative or back-up NHEJ (B-NHEJ) pathway has emerged which operates preferentially under C-NHEJ defective conditions. Although B-NHEJ appears particularly relevant...

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Detalhes bibliográficos
Main Authors: Cheng, Qiao, Barboule, Nadia, Frit, Philippe, Gomez, Dennis, Bombarde, Oriane, Couderc, Bettina, Ren, Guo-Sheng, Salles, Bernard, Calsou, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239177/
https://ncbi.nlm.nih.gov/pubmed/21880593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr656
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