Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein

In humans, DNA double-strand breaks (DSBs) are repaired by two mutually-exclusive mechanisms, homologous recombination or end-joining. Among end-joining mechanisms, the main process is classical non-homologous end-joining (C-NHEJ) which relies on Ku binding to DNA ends and DNA Ligase IV (Lig4)-media...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Yuan, Ying, Britton, Sébastien, Delteil, Christine, Coates, Julia, Jackson, Stephen P., Barboule, Nadia, Frit, Philippe, Calsou, Patrick
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666393/
https://ncbi.nlm.nih.gov/pubmed/26350212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv894
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