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Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex
The critical immortalizing activity of the human papillomavirus (HPV) type-16 E6 oncoprotein is to induce expression of hTERT, the catalytic and rate-limiting subunit of telomerase. Additionally, E6 binds to a cellular protein called E6-associated protein (E6-AP) to form an E3 ubiquitin ligase that...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC517520/ https://ncbi.nlm.nih.gov/pubmed/15371341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1214704 |
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