Cytoplasmic Poly(A) Binding Proteins Regulate Telomerase Activity and Cell Growth in Human Papillomavirus Type 16 E6-Expressing Keratinocytes

The high-risk human papillomavirus (HPV) E6 and E7 oncoproteins are critical to the immortalization of keratinocytes. HPV type 16 (HPV16) E6 interacts with endogenous proteins to activate hTERT, the catalytic subunit of telomerase, thus avoiding cellular senescence signals. NFX1-123, the longer spli...

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Bibliographic Details
Main Authors: Katzenellenbogen, Rachel A., Vliet-Gregg, Portia, Xu, Mei, Galloway, Denise A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004306/
https://ncbi.nlm.nih.gov/pubmed/20943973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01377-10
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