Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex

The critical immortalizing activity of the human papillomavirus (HPV) type-16 E6 oncoprotein is to induce expression of hTERT, the catalytic and rate-limiting subunit of telomerase. Additionally, E6 binds to a cellular protein called E6-associated protein (E6-AP) to form an E3 ubiquitin ligase that...

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Bibliographic Details
Main Authors: Gewin, Lindy, Myers, Hadley, Kiyono, Tohru, Galloway, Denise A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC517520/
https://ncbi.nlm.nih.gov/pubmed/15371341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1214704
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