A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

Although the PINK1-PARK2 pathway contributes to the pathogenesis of Parkinson disease, its roles in sepsis (a major challenge for critical care) were previously unknown. Here, we show that pink1(−/−) and park2(−/−) mice are more sensitive to polymicrobial sepsis-induced multiple organ failure and de...

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Dades bibliogràfiques
Publicat a:Autophagy
Autors principals: Kang, Rui, Zeng, Ling, Xie, Yangchun, Yan, Zhengwen, Zhou, Borong, Cao, Lizhi, Klionsky, Daniel J., Tracey, Kevin J., Li, Jianhua, Wang, Haichao, Billiar, Timothy R., Jiang, Jianxin, Tang, Daolin
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Basic Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173260/
https://ncbi.nlm.nih.gov/pubmed/27754761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1239678
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