Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a medicinal plant-derived naphthoquinone, has been reported to exhibit antiinflammatory activity...

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Publicat a:Mol Med
Autors principals: Zhang, Zhaoxia, Deng, Wenjun, Kang, Rui, Xie, Min, Billiar, Timothy, Wang, Haichao, Cao, Lizhi, Tang, Daolin
Format: Artigo
Idioma:Inglês
Publicat: Feinstein Institute for Medical Research 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004715/
https://ncbi.nlm.nih.gov/pubmed/26982513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00250
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