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ALK is a therapeutic target for lethal sepsis

Sepsis, a life-threatening organ dysfunction caused by infection, is a major public health concern with limited therapeutic options. We provide evidence to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during le...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Transl Med
Hauptverfasser: Zeng, Ling, Kang, Rui, Zhu, Shan, Wang, Xiao, Cao, Lizhi, Wang, Haichao, Billiar, Timothy R., Jiang, Jianxin, Tang, Daolin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737927/
https://ncbi.nlm.nih.gov/pubmed/29046432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan5689
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