Lipid Peroxidation Drives Gasdermin D-mediated Pyroptosis in Lethal Polymicrobial Sepsis

Sepsis is a life-threatening condition caused by pathogen infection and associated with pyroptosis. Pyroptosis occurs upon activation of proinflammatory caspases and their subsequent cleavage of gasdermin D (GSDMD), resulting in GSDMD N-terminal fragments that form membrane pores to induce cell lysi...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Kang, Rui, Zeng, Ling, Zhu, Shan, Xie, Yangchun, Liu, Jiao, Wen, Qirong, Cao, Lizhi, Xie, Min, Ran, Qitao, Kroemer, Guido, Wang, Haichao, Billiar, Timothy R., Jiang, Jianxin, Tang, Daolin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043361/
https://ncbi.nlm.nih.gov/pubmed/29937272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.05.009
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