Chloroquine Inhibits HMGB1 Inflammatory Signaling and Protects Mice from Lethal Sepsis

Sepsis is caused by an overwhelming immune response to bacterial infection. The discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal sepsis has prompted investigation into the development of new therapeutics which specifically target this protein. Here, we show that chloroquin...

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Bibliografiske detaljer
Main Authors:	Yang, Minghua, Cao, Lizhi, Xie, Min, Yu, Yan, Kang, Rui, Yang, Liangchun, Zhao, Mingyi, Tang, Daolin
Format:	Artigo
Sprog:	Inglês
Udgivet:	2013
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3713089/ https://ncbi.nlm.nih.gov/pubmed/23707973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.05.013
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Chloroquine Inhibits HMGB1 Inflammatory Signaling and Protects Mice from Lethal Sepsis

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