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Chloroquine Inhibits HMGB1 Inflammatory Signaling and Protects Mice from Lethal Sepsis
Sepsis is caused by an overwhelming immune response to bacterial infection. The discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal sepsis has prompted investigation into the development of new therapeutics which specifically target this protein. Here, we show that chloroquin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3713089/ https://ncbi.nlm.nih.gov/pubmed/23707973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.05.013 |
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