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Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy

Acute promyelocytic leukemia (APL) results from a blockade of granulocyte differentiation during the promyelocytic stage. As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-α (RARα), PML-RARα oncoprotein is degraded through the differentiation of all-trans retinoic acid (...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Yang, Liangchun, Chai, Wenwen, Wang, Yanping, Cao, Lizhi, Xie, Min, Yang, Minghua, Kang, Rui, Yu, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396052/
https://ncbi.nlm.nih.gov/pubmed/25973309
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